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May 1963

Idiopathic Hypoparathyroidism in the Newborn: Report of Two Cases Born of Diabetic Mothers

Author Affiliations

Ralph H. Kunstadter, M.D., 664 N. Michigan Ave., Chicago 11, Ill.; From the Division of Pediatrics, Michael Reese Hospital and Medical Center.

Am J Dis Child. 1963;105(5):499-506. doi:10.1001/archpedi.1963.02080040501014

Although idiopathic hypoparathyroidism is an uncommon disease, the incidence of onset in childhood is relatively high. In a review of the literature in 1952, Steinberg reported the onset of the disease before 16 years of age in 34 of 52 patients.1 Of these, only 2 became symptomatic during the first years of life and none during the neonatal period. Often the diagnosis was made in adult life, and the onset in infancy or childhood was established only by history. Bronsky et al.2 and Kopin and Rosenberg 3 also emphasized the fact that symptoms occurred in more than two-thirds of the patients before the age of 16. Furthermore, the number of infants under 1 year of age reported to have had hypoparathyroidism are few; an 11-day-old infant reported by Rhyne and Carriker4; a neonatal infant followed by one of us (M. C.) and cited by Harrison,5 and

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