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Article
September 1963

The Pickwickian Syndrome: Studies on Ventilation and Carbohydrate Metabolism: Case Report of a Child Who Recovered

Author Affiliations

BALTIMORE
Jordan W. Finkelstein, HLH 511, Johns Hopkins Hospital, Baltimore, Md.; Fellow in Pediatric Endocrinology. Dr. Jordan W. Finkelstein is sponsored by Traineeship Grant No. 2 A 5219, US Public Health Service.; John and Mary R. Markle Scholar in Academic Medicine (Dr. Avery).; From the Department of Pediatrics, Johns Hopkins University, and The Harriet Lane Home.

Am J Dis Child. 1963;106(3):251-257. doi:10.1001/archpedi.1963.02080050253002
Abstract

Introduction  The rarity of extreme obesity in childhood, and the even greater rarity of hypoventilation secondary to obesity is suggested by the paucity of children with the Pickwickian syndrome previously reported1-3,17 (Table 1). The cardiorespiratory syndrome of obesity with polycythemia, arterial unsaturation, somnolence, hypercapnia, and pulmonary hypertension, found in approximately 10% of extremely obese adults, may be fatal if unrecognized, and may be reversible with weight loss.The purpose of this report is to present the course of the first child proved to have alveolar hypoventilation in association with obesity; to consider the causal factors of her hypoventilation; to discuss her carbohydrate metabolism, and to present ventilatory studies on other obese children.

Case History  A 4½-year-old female was admitted to The Johns Hopkins Hospital for evaluation of extreme obesity, which had been present since the age of 6 months. From the family history it was learned that several cases

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