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October 1963

Studies of Anabolic Steroids: II. The Effect of Oxandrolone on Height and Skeletal Maturation in Mongoloid Children (A Preliminary Report)

Author Affiliations

Vincent C. Kelley, MD, University of Washington, Seattle 5, Wash.; From the Department of Pediatrics, University of Washington, Seattle, and Rainier State School, Buckley, Wash.

Am J Dis Child. 1963;106(4):375-380. doi:10.1001/archpedi.1963.02080050377006

Oxandrolone is a new experimental anabolic steroid chemically related to testosterone and described structurally as 17-beta-hydroxy-17-alpha-methyl-2-oxa-5 -alpha-androstan-3-one. This compound, which was synthesized by Pappo and Jung,1 is unique among anabolic steroids in that it has an oxygen atom substituted for the carbon atom at position number 2 of the phenanthrene nucleus; all previously available anabolic steroids have had an intact phenanthrene nucleus and have differed from testosterone in structure only by alterations in the numbers and positions of atoms or chemical groups attached to this nucleus.

Preliminary studies of oxandrolone in animals suggested that this compound has anabolic effects similar to norethandrolone but androgenicity less than 1% of that seen with testosterone.2 In adult human subjects, as indicated by the "steroid protein activity index (SPAI)," Albanese, Lorenze, and Orto 3,4 found oxandrolone to compare favorably in protein anabolic properties with the most potent anabolic steroids tested: testosterone propionate,

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