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October 1963

Anabolic Effects of Stanozolol: Reversal of Growth Arrest and Possible Changes in Adult Height Prognosis Among Children With Intractable Asthma Treated With Corticosteroids

Author Affiliations

Constantine J. Falliers, MD, 3401 W 19th Ave, Denver 4, Colo.; From the Children's Asthma Research Institute and Hospital, 3401 W 19th Ave.

Am J Dis Child. 1963;106(4):388-401. doi:10.1001/archpedi.1963.02080050390008

Many chronic or recurrent illnesses are known to have an adverse effect on the growth of children.1-3 This growth inhibition, though possibly related in part to such nonspecific factors as nutrition and physical activity, appears to depend primarily on the type and severity of the particular disorder.4-7

Several studies have indicated that a significant number of children with asthma fail to grow adequately when the disease is active but may show a "growth repair" when symptoms subside.8-10 A very marked retardation of growth has been observed among children with intractable asthma in residence at the Children's Asthma Research Institute and Hospital (CARIH) in Denver.11,12 A four-year study of 302 patients at CARIH revealed that 20% of these children were under the third percentile or three to six standard deviations below the mean for their age and sex. During an 18-to 24-month stay at the Institute, those