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October 1963

Thrombocytopenic Purpura With Infectious Mononucleosis: Two Cases in Children with Review of the Literature

Author Affiliations

Lt Col John P. Fairchild, MC, USA, Tripler General Hospital, Office of the Chief of Pediatric Service, APO 438, San Francisco, Calif.

Am J Dis Child. 1963;106(4):415-418. doi:10.1001/archpedi.1963.02080050417011

There have been many reports of the varied complications that have occurred in conjunction with infectious mononucleosis. The association of thrombocytopenia and infectious mononucleosis has been reviewed several times in the adult literature.1,2 This report represents the first such review in children and adds two additional cases.

In order to conclude accurately that infectious mononucleosis is the basic process underlying any clinical picture we must have rigid criteria for diagnosing this entity. Hoagland3 states that both the heterophil agglutination test and blood picture must be characteristic before the diagnosis is established. The following case histories represent well-documented instances of thrombocytopenia occurring during the course of infectious mononucleosis.

Case 1.—A Caucasian male, three years and ten months old, was in a good state of health until ten days prior to admission when he developed a few petechiae on his arms and later the same day began to bruise easily.

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