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Article
January 1964

Gastrointestinal Protein Leakage in Celiac DiseaseAs Studied by Labeled PVP

Am J Dis Child. 1964;107(1):58-66. doi:10.1001/archpedi.1964.02080060060009
Abstract

The celiac affection as described by Gee in 1888 embraced various abdominal diseases.1 Since then many entities have been excluded from the original concept and have attained nosological independence: fibrocystic disease of the pancreas,2 upper intestinal infestation (lambliasis, moniliasis),3,4 deficiency of bile salts,5 and tuberculous enteritis.6 Following the work of Dicke,7 van de Kamer,8 Weijers,9 Sheldon,10 Frazer,11 and others 12-14 on the harmful influence of gluten and its toxic fraction,15-17 and following the histological examinations of the intestinal wall performed by Doniach-Shiner,18 and Rubin,19 it has been assumed that gluten-induced enteropathy refers to celiac disease of children and to nontropical sprue, or adult celiac disease, representing an additional entity separated out from the over-all celiac syndrome.

In the common clinical description of celiac disease there is, in addition to the constant findings of pale, bulky, offensive stools with

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