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March 1964

Beta-Hemolytic Streptococcal Infections In Children: Comparison of the Therapeutic Effectiveness of Potassium Penicillin G, Tetracycline Phosphate Complex, and Demethylchlortetracycline

Author Affiliations

Burtis B. Breese, MD, 2333 Elmwood Ave, Rochester, NY 14618.; Clinical Professor Pediatrics (Dr. Breese), Clinical Associate Professor (Dr. Disney), Senior Clinical Instructor (Dr. Talpey), University of Rochester School of Medicine and Dentistry.; From the Department of Pediatrics, University of Rochester School of Medicine and Dentistry.

Am J Dis Child. 1964;107(3):232-239. doi:10.1001/archpedi.1964.02080060234003

In our continuing investigations of therapeutic agents for β-hemolytic streptococcal infections in children, four oral antibiotics were tested between Dec 15, 1959, and March 15, 1960. They were: buffered potassium penicillin G (Pentids), potassium phenethecillin (Syncillin, and Chemipen), tetracycline phosphate complex (Sumycin), and demethylchlortetracycline (Declomycin). Two of these, phenethecillin and demethylchlortetracycline, were then relatively recent additions to the antibiotic field. It was hoped to determine by therapeutic trial whether these two newer products were superior to the older analogues, sodium penicillin G and tetracycline complex, in the treatment of streptococcal infections in children. We also wished to determine whether there was any evidence that tetracycline resistant streptococci had appeared in our community. Such resistance had been described by Mogabgab and Pelon in 1958,6 and since this study by Kuharic, Roberts, and Kirby (1960)7 and McCormack, Kaye, and Hook in 1962.4 In addition we conducted a small therapeutic