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March 1964

Congenital Cutaneous Candidiasis

Author Affiliations

Harry Sonnenschein, MD, 2020 Dorchester Rd, Brooklyn, NY, 11226.; Attending Pediatrician, Maimonides Hospital; Clinical Assistant Professor of Pediatrics, Downstate Medical Center, State University of New York (Dr. Sonnenschein); Research Associate, Pediatrics, Maimonides Hospital: Lecturer in Dermatology, Downstate Medical Center, State University of New York (C. L. Taschdjian); Assistant Attending Obstetrician, Maimonides Hospital; Clinical Instructor in Obstetrics and Gynecology, Downstate Medical Center, State University of New York (Dr. Clark).; From the Pediatric Departments of the Maimonides Hospital of Brooklyn, and the Department of Pediatrics, Downstate Medical Center, State University of New York.

Am J Dis Child. 1964;107(3):260-266. doi:10.1001/archpedi.1964.02080060262007

Introduction  Neonatal candidiasis, contracted during passage through the vagina and erupting clinically during the first two weeks of life, is a commonplace occurrence. On the other hand, candidal infection contracted in utero and clinically manifest at birth is extremely rare. The few cases recorded in the literature indicate that systemic rather than cutaneous infection is the rule and that the outcome is usually fatal.1,2In 1960 we reported what we believe to be the first case of prenatally contracted cutaneous candidiasis.3 In that case the intrauterine origin of the infection was inferred from the presence at birth of well-advanced, extensive candidal skin lesions. Premature rupture of the membranes, permitting ascending candidal contamination of the uterine cavity and its contents, furnished a plausible explanation for the pathogenesis of the fetal infection. Intensive administration of antibiotics during the last 17 days before delivery may have been a contributory factor.The