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March 1964

Thyroid Function Tests: Findings in Arkansas Children and Young Adults

Author Affiliations

D. A. Fisher, MD, University of Arkansas Medical Center, Little Rock, Ark 72201.; Department of Pediatrics (Dr. Fisher), Department of Radiology (Dr. Oddie), Division of Biometrics (J. C. Wait), the University of Arkansas Medical Center.

Am J Dis Child. 1964;107(3):282-287. doi:10.1001/archpedi.1964.02080060284011

Introduction  Thyroid function during the first weeks of life is characterized by hyperactivity as measured by increased radioiodine uptake, increased serum hormonal iodine values, and increased erythrocyte triiodothyronine I131 uptake. This neonatal thyroid hyperactivity subsides within one to two weeks and the elevated test results have returned to normal childhood levels by 8 to 12 weeks of age.1 There are relatively few reports characterizing and correlating thyroid function tests during childhood subsequent to this period. Radioiodine uptake tests on normal children summarized by Andersen2 and Diwany et al3 have been, for the most part, late uptake studies (24-48 hours) and have shown considerable variation with geographic area. Adequate comparisons with adult values by similar methodology and characterization of I127 excretion have generally not been available.Investigations of serum hormonal iodine values in normal children have been few.4-6 Values have been reported to be significantly