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April 1964

Silver Syndrome: A Report of Two Cases and a Review of the Literature

Author Affiliations

Capt Henry C. Reister, MC, USA, Walter Reed General Hospital, Washington, DC 20012.

Am J Dis Child. 1964;107(4):410-416. doi:10.1001/archpedi.1964.02080060412014

Introduction  In 1953, H. K. Silver 1 described two children who demonstrated shortness of stature, hemihypertrophy, and elevated gonadotropins. In the intervening years he has reported three additional children2,3 with the same clinical pattern. A few other cases which are susceptible to classification with Silver's have appeared in the literature. A variety of associated findings in these children have become apparent. Two unreported cases of what we shall henceforth call the "Silver syndrome" have been seen at Walter Reed General Hospital in the past year. Both patients were referred for evaluation of growth retardation. Hemihypertrophy had been previously noted in both but was considered only as an incidental finding.

Report of Cases  Case 1.—The patient (Fig 1) was a 3½-year-old Caucasian male born May 28, 1959, after an uneventful pregnancy to a 30-year-old Caucasian gravida III para II mother and a 29-year-old Caucasian father. Although this gestation was 40