The evaluation of prolonged obstructive jaundice in infancy, involving primarily the differential diagnosis between "giant-cell hepatitis" and biliary atresia, remains a difficult clinical problem. In spite of reports concerning the diagnostic usefulness of cholagogue administration, duodenal intubation, SGOT determinations,1 administration of corticosteroids,2 and employment of radioactive rose bengal I131,3 the precise diagnosis is generally obtained by liver biopsy and cholangiography. The clinician has found it necessary to balance the increased dangers of the operative diagnostic procedure in those infants with hepatitis,4-6 against the dangers of rapidly progressive and irreversible hepatic fibrosis in untreated atresias, which might otherwise be curable by surgery.7-11 Regardless of the clinician's talents and skills, errors in this situation are recurrent, particularly since the coexistence of atresia and hepatitis in the same infant has now been established in several instances.12-15,17,27 The difficulty of diagnosis has been increased by
CASSADY G, MORRISON AB, COHEN MM. Familial "Giant-Cell Hepatitis" in Infancy: Clinical, Pathologic, and Genetic Studies on a Large Family. Am J Dis Child. 1964;107(5):456–469. doi:10.1001/archpedi.1964.02080060458005
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: