The determination of the prothrombin time, particularly the prothrombin content of plasma, is a useful but often neglected liver function test in the adult.1-4 It occurred to us that similar studies might be of value in infancy during the period of life when most liver function tests are of equivocal value.5-7 Since preliminary studies were encouraging, it became important to determine values for prothrombin and the prothrombin complex in the normal full-term infant. These values are the subject of this report.
Materials and Methods
A total of 28 normal full-term infants were followed during the first 12 to 18 months of life. The group included 22 Negro (12 male, ten female) and six white (two male, four female) infants. Each child was regularly examined by one of us (J. S.) in a well-baby clinic. The infants' weights were recorded on each visit. All initial determinations, with two exceptions,
GLUECK HI, SUTHERLAND J, GLESER G. Prothrombin Levels During the First Year of Life: Observations Followed by the Synthetic Substrate (TAMe) Assay of Normal Full-Term Infants. Am J Dis Child. 1964;107(6):612–617. doi:10.1001/archpedi.1964.02080060614010
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