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June 1964

Renal Calculus And the Nephrotic Syndrome

Author Affiliations

Mayo Clinic, Rochester, Minn 55901.; Section of Pediatrics (Dr. Burke), Fellow in Pediatric Nephrology (Dr. Wenzl), Section of Pediatrics (Dr. Stickler), Mayo Clinic and Mayo Foundation.

Am J Dis Child. 1964;107(6):624-627. doi:10.1001/archpedi.1964.02080060626012

Urinary calculi are seldom found in pediatric patients and, when found, they often are associated with a metabolic defect or an infection. We recently discovered an asymptomatic renal calculus in a patient who had had the nephrotic syndrome for 6 years, associated with the histologic finding of chronic membranous glomerulonephritis. The unique aspect of this combination of pathologic processes prompted the investigation of some aspects of calcium and phosphorus metabolism in this patient. Survey of the literature and communication with other pediatric nephrologists failed to uncover additional cases.

Report of Case  The patient was 8½ years old when he first was seen at the Mayo Clinic in August, 1962. The chief complaint at that time was swelling of the face and extremities as a result of exacerbation of the nephrotic syndrome. The boy had been well until the age of 1 year and 9 months, at which time proteinuria and