Idiopathic transient edema and hypoproteinemia of childhood has been a recognized clinical entity for several years.1-5 Recently studies have indicated that in the absence of proteinuria, increased intestinal degradation of protein (exudative enteropathy, protein-losing gastroenteropathy) plays an important role in the genesis of the edema and hypoproteinemia.6,7 Unlike children who have had persistent edema and hypoproteinemia with increased gastrointestinal protein degradation,8-11 only one of the patients with transient idiopathic edema and hypoproteinemia has had evidence of gastrointestinal pathology. This patient, a 3-year-old child reported by Degnan,5 had "the presence and persistence of large gastric folds on gastrointestinal series, suggesting hypertrophic gastritis."
The purpose of this paper is to report a case of transient severe edema and hypoproteinemia in a 5-year-old child who was shown to have increased intestinal degradation and decreased synthetic activity of albumin associated with transient giant hypertrophy of the gastric mucosa.
PITTMAN FE, HARRIS RC, BARKER HG. Transient Edema And Hypoproteinemia: Possible Menetrier's Disease. Am J Dis Child. 1964;108(2):189–197. doi:https://doi.org/10.1001/archpedi.1964.02090010191013
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: