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August 1964

Pneumocystis Carinii Pneumonia in Wiskott-Aldrich Syndrome

Author Affiliations

Herbert D. Weintraub, MD, University of Missouri School of Medicine, Department of Radiology, Beth Israel Hospital, Boston 02115.; Assistant Professor of Radiology (Dr. Weintraub) and Resident Physician, Radiology (Dr. Wilson).; University of Missouri School of Medicine, Department of Radiology.

Am J Dis Child. 1964;108(2):198-200. doi:10.1001/archpedi.1964.02090010200014

In the past few years, there has been an increasing number of reports of pneumocystis carinii pneumonia. Usually, this has occurred in infants who suffered from some other debilitating disease. The purpose here is twofold: (1) to present a case report of this lethal pneumonia which occurred in an infant with the Wiskott-Aldrich Syndrome and (2) to emphasize the important signs that should suggest the diagnosis of pneumocystis carinii pneumonia.

Etiology.—The causative organism is felt by most to be a protozoan.10 It has been found in every case of pneumocystis carinii pneumonia, although Koch's postulates have never been satisfied. It is named after Carini,5 who described it in 1910, although Chagas6 in 1909, is generally thought to be the first to have described it. Interstitial plasma cell pneumonia has been known for many years, but in 1952,14 pneumocystis carinii was incriminated as the etiologic agent.