Nasal carriers of pathogenic strains of Staphylococcus aureus are a potential hazard to their environment, their contacts, and themselves. At present, there is no known method which permanently eradicates "virulent" strains of S aureus from the nose of all persistent carriers. These investigations were undertaken to evaluate a new approach to a solution of the problem presented by adult carriers of virulent staphylococci.
Shinefield and his associates have demonstrated that colonization of the nasal mucosa of newborns with one strain of coagulasepositive staphylococcus interferes with subsequent acquisition of a second strain of S aureus,1 and that, in fact, artificial colonization of newborns immediately after birth with a staphylococcus of low virulence can be employed to protect infants from infection by virulent "epidemic" strains.2-5 Epidemiologic data which would support the hypothesis of biologic competition between different strains of staphylococci have been reported by other groups of investigators.6-8
BORIS M, SELLERS TF, EICHENWALD HF, RIBBLE JC, SHINEFIELD HR. Bacterial Interference: Protection of Adults Against Nasal Staphylococcus Aureus Infection After Colonization With a Heterologous S Aureus Strain. Am J Dis Child. 1964;108(3):252–261. doi:10.1001/archpedi.1964.02090010254006
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