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September 1964

Colistin Suppression of Escherichia Coli In Stools: I. Control of a Nosocomial Outbreak of Diarrhea Caused by Neomycin-Resistant Escherichia Coli 0111: B4

Author Affiliations

Warren E. Wheeler, MD, University of Kentucky, Medical Center, College of Medicine, Department of Pediatrics, Lexington, Ky 40506.; From the Department of Pediatrics, Children's Hospital.

Am J Dis Child. 1964;108(3):274-277. doi:10.1001/archpedi.1964.02090010276009

Recently, Kessner et al1 reported an extensive epidemic due to enteropathogenic Escherichia coli (EPEC) which occurred during the winter of 1960-1961 in the metropolitan Chicago-northwestern Indiana region. This report prompted us to recount our experience with a nosocomial epidemic, sparked by the Chicago outbreak, which plagued our hospital for a period of three months. Our epidemic started late in July, 1961, and was attributed to 8-month-old twins admitted with diarrhea. Their 18-month-old sibling had been discharged from a Chicago hospital two weeks previously. The epidemic involved 27 infants (25 of them cross-infections in our hospital) and contributed to the death of six children. During the preceding six years, suppression of contagion of EPEC by a neomycin sulfate "umbrella" was successful in reducing contagion in diarrhea patients admitted to the Children's Hospital, Columbus, Ohio.2 All newly admitted diarrhea patients under 2 years of age were given oral neomycin