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October 1964

Renal Vein Thrombosis In Infancy: Recovery Without Nephrectomy

Author Affiliations

Harry Stark, MB, BS, DCH, MRCPE, 8, Zedekiah St, Haifa, Israel.; Department of Pediatrics B, Rambam Government Hospital.; From the Pediatric Department A, Kaplan Hospital, Rehovoth, Israel, and the Pediatric Department B, Rambam Government Hospital.

Am J Dis Child. 1964;108(4):430-435. doi:10.1001/archpedi.1964.02090010432015

"Renal thrombosis in infants and children is an exceedingly grave condition and terminates fatally in practically every case not promptly treated surgically." 1 "When there is unilateral involvement (with hemorrhagic infarction of the kidneys) prompt nephrectomy is employed."2 "Survival (in cases of unilateral renal vein thrombosis in children) will largely depend on immediate exploration and nephrectomy."3

The above quotations typify the widespread belief1-6 that in an infant the diagnosis of renal vein thrombosis necessitates immediate nephrectomy as an urgent, lifesaving procedure.

Experience with three infants with the clinical diagnosis of renal vein thrombosis who recovered without surgery prompted a review of the literature on the subject. This yielded additional data which suggested the need for a reappraisal of the entire question of therapy of this serious condition.

Report of Cases  Case 1.—The child of a diabetic mother was born, weighing 3.8 kg (8 lb, 8 oz). He