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November 1964

Measles Vaccination In Infants: Use of Killed-Live Combinations

Author Affiliations

Alexander E. Russell, MD, Department of Preventive Medicine, University of Washington, Seattle, Wash 98105.; Assistant Professor and Markle Scholar in Medical Science, Department of Preventive Medicine, University of Washington (Dr. Alexander), Staff pediatrician, Group Health Cooperative of Puget Sound (Dr. Bansmer, Dr. Harris).; From the Department of Preventive Medicine, University of Washington, School of Medicine and the Department of Pediatrics, Group Health Cooperative of Puget Sound.

Am J Dis Child. 1964;108(5):470-478. doi:10.1001/archpedi.1964.02090010472005

Measles vaccination as developed by Enders and others has been proven safe and efficacious.1,2 Modification of clinical response to attenuated measles infection by simultaneous administration of immune globulin has become the most widely used method in the United States.3-9 However, even in this country, where natural exposure to measles virus is more apt to take place after age 2, the early protection of infants remains a problem. It is of greater importance to areas of the world where measles characteristically occurs before the second birthday.10-12

An alternative method of modifying attenuated measles vaccine has been prior inoculation of inactivated vaccine in 1, 2, or 3 doses.9,13-15 Feldman16 and Karelitz17 have reported that infants who had received prior inactivated vaccine, when challenged with mild measles or live attenuated measles virus vaccine exhibited antibody production with minimal reaction. It appeared that this might be worthy of