In 1933, Cornelia de Lange1 of Amsterdam called attention to the first of a group of children2-14 with a syndrome whose principal clinical findings include a typical facies with a small nose, anteverted nostrils, a thin, downturned mouth, eyebrows that meet in the midline, and long, curly eyelashes, as well as abnormally small limbs, flexion contracture of the elbows, a low-pitched, growling cry, short stature, and mental retardation. The syndrome has recently been comprehensively reviewed by Jervis and Stimson15 and by Ptacek and co-workers.16 This report presents an additional typical case of the de Lange syndrome and notes the findings in 44 known cases.2-22
Report of a Case
This white Jewish female was born after a 37-week gestation and weighed 2,120 gm (4 lb 11 oz). Fetal movements were reportedly normal. The mother, who was 29 years old, had been well during pregnancy. She had
SILVER HK. The de Lange Syndrome: Typus Amstelodamensis. Am J Dis Child. 1964;108(5):523–529. doi:https://doi.org/10.1001/archpedi.1964.02090010525011
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