[Skip to Content]
[Skip to Content Landing]
November 1964

Fetal Ascites—Liver Giant-Cell Transformation: Report of a Case With Recovery

Author Affiliations

From the Childrens Hospital of Los Angeles.

Am J Dis Child. 1964;108(5):554-558. doi:10.1001/archpedi.1964.02090010556016

Massive ascites present at birth without generalized edema is a rare manifestation with a grave prognosis. Three large groups of underlying anatomical abnormalities have been implicated in the pathogenesis of this disorder. Baghdassarian,1 in a recent review, lists: (a) intestinal anomalies, especially perforation of the bowel secondary to malformation; (b) portohepatic abnormalities with obstruction of the portal circulation; and (c) anomalies of the lower urinary tract. A fourth group of miscellaneous causes includes cases of chylous ascites. Of approximately 165 reported cases in all four groups, only four infants survived beyond the neonatal period. The purpose of this report is to describe what we believe to be the first instance of massive ascites in a newborn infant with giant-cell transformation of the hepatic parenchymal cells.

Report of a Case  The patient was a 6 lb, 10 oz (3,006 gm), Caucasian male admitted to the Childrens Hospital of Los Angeles