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December 1964

Erythrocyte Morphology in Hemolytic Disease: In the Newborn

Author Affiliations

Capt John Mann, USAF (MC), Pediatric Service USAF Hospital, Eglin AFB, Fla.; Department of Pediatrics, Wilford Hall USAF Hospital, Aerospace Medical Division (AFSC), Lackland Air Force Base, Tex.

Am J Dis Child. 1964;108(6):611-616. doi:10.1001/archpedi.1964.02090010613005

Introduction  Hemolytic disease of the newborn due to ABO blood group incompatibility is a disease entity which is often difficult to diagnose with certainty despite advanced techniques in immunohematology. However, certain specific differences are noted between ABO hemolytic disease (ABO-HD) and hemolytic disease of the newborn due to other blood group incompatibilities, such as the severity of involvement, involvement of the firstborn, frequently negative direct Coombs' test and the presence of spherocytes. The use of more sensitive Coombs' sera has increased the frequency of positive direct Coombs' tests in ABO-HD.1 On the other hand, false positive direct Coombs' tests have been noted1 and the possibility of a decreased specificity of these sera must be considered. The presence of spherocytosis in ABO-HD has been reported by many investigators but has neither been accurately defined nor adequately understood.2-10 The present study was undertaken to delineate the spherocyte as it