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January 1965

Relationship of Mumps to Endocardial Fibroelastosis: Complement-Fixation, Hemagglutination-Inhibition And Intradermal Skin Tests for Mumps in Children With and Without Endocardial Fibroelastosis

Am J Dis Child. 1965;109(1):69-73. doi:10.1001/archpedi.1965.02090020071008

PRIMARY ENDOCARDIAL fibroelastosis has been recognized as a distinct entity characterized by endocardial thickening involving either or both left and right sides of the heart. It is unassociated with other cardiac anomalies and usually occurs in infancy. Recent investigations1-6 have emphasized the clinical features of this disease in infants, thus facilitating an accurate antemortem diagnosis and institution of therapy.

The hypothesis that the endocardial thickening is a manifestation of an intrauterine infection has been revived recently by Noren et al.7 These investigators demonstrated the presence of a positive reaction to mumps antigen injected intradermally in all of nine children with a clinical diagnosis of endocardial fibroelastosis. There was a history of exposure to mumps in two of the mothers and clinical mumps was present during the first trimester of pregnancy in another of the nine mothers. Noren concluded that intrauterine infection with the mumps virus in the first