HAND-FOOT AND-FOOT SYNDROME is the term used to describe painful, usually symmetrical, swellings of the hands and feet of infants with sickle cell disease.1,2 In the absence of infection, this manifestation is presumably due to bone infarction. Symptoms in the average case persist for one or two weeks. Roentgenographic changes of subperiosteal new bone formation and irregular areas of radiolucency may appear seven to 14 days after the onset of symptoms. These changes usually disappear completely after a few weeks.
Fever and painful swellings simulate osteomyelitis; however, Watson et al,2 in a recent review article of the hand-foot syndrome, stated that osteomyelitis involving small bones of the hands and feet symmetrically has never been described.
The purpose of this report is to present the case of an infant with a "hand-foot syndrome" due to group A β-hemolytic streptococcal infection.
Report of a Case
Presenting Illness.—An 8-month-old Negro
HALTALIN KC, NELSON JD. Hand-Foot Syndrome Due to Streptococcal Infection. Am J Dis Child. 1965;109(2):156–159. doi:10.1001/archpedi.1965.02090020158012
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.