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February 1965

The Background of Chemotherapy of Virus Diseases.

Am J Dis Child. 1965;109(2):183-184. doi:10.1001/archpedi.1965.02090020185025

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This small book offers a brief and understandable resumé of the progress in the field of viral chemotherapy. The authors state in the introduction that its content will be familiar to virologists but they hope "it will be useful to those who seek to understand why progress against the viruses is apparently so slow." The first chapter is a brief summary of the present understanding of the chemical composition and multiplication of viruses; this is followed by chapters on the pathology of viral infections, Interferon and virus interference, experimental chemotherapy, evaluation of chemotherapy in human infections, and a final chapter on the treatment of secondary bacterial infections.

In the chapter on assessment of chemotherapy in human infections the reported studies with 5-iodo-2-deoxyuridine (IUDR), N-methylisatin-β-thiosemicarbazone and N'N'-anhydrobis-(β-hydroxyethyl) biguanide hydrochloride (ABOB) are nicely summarized. The authors point out the necessity of rigorously controlled clinical trials, especially in the relatively mild, self-limited viral

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