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March 1965


Author Affiliations

University of Washington Seattle, Wash 98105

Am J Dis Child. 1965;109(3):261. doi:10.1001/archpedi.1965.02090020263013

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To the Editor: The recent paper by Dr. Woody on "Hyperlysinemia" (Amer J Dis Child 108:543, 1964) is of considerable interest in that it may represent a new type of metabolic error, namely a defect in the transcription of genetic information.

In the last several years the exciting work of many investigators has clarified the process by which the genetic code is translated for protein synthesis. This chain of events consists of the elaboration by DNA of complementary messenger RNA which passes from the nucleus to the cytoplasm where, in association with ribosomal RNA, it forms a template which prescribes a given order of arrangement of transfer RNA molecules. Each transfer RNA molecule carries a specific amino acid which when placed in a given order by the messenger RNA forms a polypeptide chain representing the dictates of the original DNA code. The amino acid is placed on the transfer RNA

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