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Article
April 1965

The Treatment of Acute Otitis Media in Children: III. A Third Clinical Trial

Author Affiliations

ROCHESTER, MINN
From the Mayo Clinic and Mayo Foundation. Fellow in Pediatrics (Dr. Rubenstein), Section of Otolaryngology and Rhinology (Drs. McBean and Hedgecock), and Section of Pediatrics (Dr. Stickler).

Am J Dis Child. 1965;109(4):308-313. doi:10.1001/archpedi.1965.02090020310008
Abstract

THE management of acute otitis media in children varies widely among clinicians and institutions. Points of disagreement include the advisability of myringotomy,1-8 the choice of antimicrobial agents,3,9-13 the effectiveness of antihistamines and decongestants, and the length of treatment. Accurate microbiologic diagnosis is not possible except by needle aspiration of the middle ear cavity through the tympanic membrane,5,8,14 an obviously impractical approach. It was thus decided to evaluate regimens by means of a series of clinical trials, the results of two of which have already been reported.15,16 Because of the danger of complicating mastoiditis and meningitis,3,17-19 we felt that all patients should receive an antimicrobial drug, although we realized that we would thereby probably be treating unnecessarily a number of patients with otitis media related to viral disease.

Previous investigations by this group15,16 indicated that sulfonamides are not as effective as tetracyclines in the management

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