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May 1965

Wilms's Tumor and Associated Anomalies

Author Affiliations

From the Department of Pediatrics, St. Vincent's Hospital and Medical Center of New York. Director of Pediatrics (Dr. Fontana).

Am J Dis Child. 1965;109(5):459-461. doi:10.1001/archpedi.1965.02090020461016

WILMS'S tumor, one of the most common abdominal neoplasms of childhood, has been reported to be associated with certain congenital anomalies. Miller et al1 of the National Institute of Health, reviewed a series of 440 cases of Wilms's tumor in association with aniridia, hemihypertrophy, pigmented nevi and hemangiomas, hypospadias, cryptorchidism, horseshoe kidney, and duplication of the upper urinary tract.

The more common anomalies associated with aniridia and Wilms's tumor, and the cases reported in the literature, are noted in the Table. A survey by Miller1 indicates that only six cases of Wilms's tumor have been reported having aniridia as one of the associated congenital anomalies. The presence of Wilms's tumor with aniridia, cataracts, recurved pinna of the ear, and duplication of the upper urinary tract has occurred in one of our patients.

A diagnosis of Wilms's tumor should be suspected and considered in the differential diagnosis when a

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