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June 1965

Thiabendazole in Pinworm Infestations

Author Affiliations

From the Palo Alto Medical Research Foundation and the Palo Alto Medical Clinic. Associate Clinical Professor Pediatrics, Stanford University School of Medicine.

Am J Dis Child. 1965;109(6):567-570. doi:10.1001/archpedi.1965.02090020569012

THIABENDAZOLE HIABENDAZOLE * (2- (4′ Thiazolyl)-benzimidazole) has been used extensively as a veterinary anthelmintic. More recently it has been employed in the treatment of various human parasitic infestations, including strongyloidiasis, ascariasis, hookworm, trichuriasis, creeping eruption, and trichinosis.1-8 Early reports on the use of this drug in enterobiasis have been encouraging.9 An 83%-93% conversion rate following a single dose of thiabendazole in emulsion form was reported by Iwata et al.10 To date, there have been no clinical reports on thiabendazole in pinworm infestations published in the American literature. This is a report of a study to determine the efficacy and acceptance of this drug in a double blind study with pyrvinium pamoate (Povan (R)) and a placebo.

Chemistry and Pharmacology †  Thiabendazole is a white, tasteless, crystalline compound, which melts with decomposition at 298-299 C. It is a stable compound both as a solid and in solution. It is