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July 1965

Encephalopathy, Hepatitis and Fat Accumulation in Viscera

Author Affiliations

From the departments of pediatrics and pathology, Danbury Hospital, Danbury, Attending Pediatrician, Danbury Hospital and Clinical Instructor in Pediatrics, Yale University School of Medicine, New Haven, Conn (Dr. Randolph); Resident in Pathology, Danbury Hospital (Dr. Kranwinkel); Public Health Service, Survival and Communicable Disease Center, Atlanta (Dr. Johnson); and Associate Pathologist, Danbury Hospital and Clinical Instructor in Pathology, Yale University School of Medicine (Dr. Gelfman).

Am J Dis Child. 1965;110(1):95-99. doi:10.1001/archpedi.1965.02090030101017

Introduction  A PECULIAR, frequently fatal syndrome in children, thought somehow to be related to viral infection, has recently been reported from Australia.1 Characteristically, a mild illness with respiratory and gastrointestinal symptoms of three to five days duration terminates in a 24-hour period of acute cerebral deterioration with disorientation, convulsions, and coma. The major postmortem findings are fatty liver and cerebral edema.An 8-year-old child with such a fatal illness was observed at Danbury Hospital in October 1963. Shortly thereafter, a similar nonfatal illness was observed in a younger sibling. Three other fatalities with similar clinical and autopsy features occurred in a neighboring state within a few weeks of our own case. It is our purpose to alert readers to the possible occurrence of the Reye syndrome in the United States.

Report of a Case  EA, an 8-year-old white boy, was admitted to the Danbury Hospital on Nov 8, 1963

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