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August 1965

Pure Gonadal Dysgenesis: Report of a Case

Author Affiliations

From the Clinique de Génétique Medicale (Drs. de Grouchy, Josso, and Bitan), Service de Pédiatrie (Prof Mallet), Hôpital des Enfants-Malades, and Professor of Pathology, Faculty of Medicine, University of Paris (Dr. Nezelof), Paris.

Am J Dis Child. 1965;110(2):203-205. doi:10.1001/archpedi.1965.02090030213022

SEX REVERSAL, defined by a female phenotype and a male chromosome complement, is seen in testicular feminization and in a rare variety of gonadal dysgenesis, namely "pure" gonadal dysgenesis.

The present report describes a girl, aged 17, whom we consider to be a case of pure gonadal dysgenesis.

Report of a Case  The patient was born from healthy nonrelated parents. Her father was 37 and her mother was 30 at the time of the patient's birth. She has a healthy brother, aged 27. The family history is unremarkable. The pregnancy was uneventful and the mother received no treatment and no x-ray therapy.The patient first sought medical advice at the age of 14 because of delayed puberty. She then received, during the next three years, three series of chorionic gonadotropin injections.At present, at the age of 17, she measures 156 cm (6 ft 1 inch) and weighs 53 kg

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