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Article
August 1965

Chondrodystrophia Calcificans Congenita: Chondrodysplasia Epiphysialis Punctata, Stippled Epiphyses

Author Affiliations

YOUNGSTOWN, OHIO

Am J Dis Child. 1965;110(2):218-225. doi:10.1001/archpedi.1965.02090030228027
Abstract

Historical  CHONDRODYSTROPHIA calcificans congenita is a rare disorder of bone, occurring in infants, which is characterized by the radiographic manifestation of discrete calcific densities in hyaline cartilage. The disease belongs in the group of multiple epiphyseal dysplasias.1The first pathological description was that of Langhans in 1893.2 The original radiographic description of chondrodystrophia calcificans congenita was by Conradi3 in a newborn female. After a lapse of 20 years the second case was reported in a male infant.4 Since then sporadic cases have been reported from all over the world. A total of approximately 110 cases have been reported over a period of 50 years by nearly as many authors thus indicating its rare occurrence. At least 60% of the total number of cases have been reported in the past 15 years and nearly 10% of the total number of cases in the past five years. This

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