THE SUBJECT of this talk, I believe, would have been dear to the heart of Dr. Mitchell. He was interested in the growth and development of children, and it is on record that among the numerous lectures and talks which he gave, beyond the confines of this institution, are listed dissertations on endocrinologic diseases in children. About the time of his birth, in 1889, the understanding of the role of the pituitary in growth was beginning to emerge from the morass of confusion which had surrounded it until then. Pituitary gigantism was a well-known syndrome; Magendie, Cushing, and Hutchinson had written accurate clinical descriptions of the grotesque individuals suffering from excessive growth of the head, limbs, trunk, tongue, hands, and fingers. The first description appeared nearly 100 years ago, but the role of the pituitary gland in the production of gigantism and acromegaly lay undiscovered for a long time, because
KAPLAN SA. Growth Hormone. Am J Dis Child. 1965;110(3):232–238. doi:10.1001/archpedi.1965.02090030246002
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