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September 1965

Lupus Glomerulonephritis: The Effect of Large Doses of Corticosteroids on Renal Function and Renal Lesions in Two Children

Author Affiliations

From the departments of pediatrics and pathology, University of California School of Medicine, Los Angeles. Assistant Professor of Pediatrics (Dr. Smith); Clinical Professor of Pediatrics (Dr. Litman); and Professor of Pathology (Dr. Latta).

Am J Dis Child. 1965;110(3):302-308. doi:10.1001/archpedi.1965.02090030316016

IN RECENT years it has become apparent that renal disease is one of the chief causes of morbidity and the major cause of death in systemic lupus erythematosus.1,2 Corticosteroids have been used extensively in the treatment of systemic lupus erythematosus and have been successful in controlling or suppressing clinical symptoms. Even though patients with lupus nephritis can be maintained relatively symptom-free with small doses of corticosteroids, the structural damage to the kidney progresses rapidly. In 1961, Pollak et al,3 reported on the effect of large doses of prednisone on the renal lesions and life span of patients with lupus glomerulonephritis. They closely followed 16 patients for six months and reported that histological signs of activity either disappeared or decreased in 10 of the 16 patients.

The purpose of this report is to describe the beneficial effects of long-term high dose corticosteroid therapy on renal function and the renal

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