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September 1965

Generalized Cytomegalic Inclusion Disease: Report of Two Cases With Associated Fungal Infection, One Involving Aspergillosis, the Second With Candidiasis

Author Affiliations

From the Department of Pediatrics and the Mallory Institute of Pathology, Boston City Hospital.

Am J Dis Child. 1965;110(3):319-328. doi:10.1001/archpedi.1965.02090030333019

SINCE RIBBERT,1 in 1904, first reported the presence of inclusion bodies in the cells of the kidney and parotid gland of a stillborn infant and Jesionek and Kiolemenoglou2 similarly cited inclusions in the cells of the kidney, liver, and lungs of another stillborn infant, cytomegalic inclusion disease has been reported frequently as a disease of newborn infants, infants beyond the neonatal period, and less commonly, older children3 and adults.4,6 We wish to report two infants with cytomegalic inclusion disease in combination with a fungal infection, since we could find no definite reports of such cases in infancy. In the first case cytomegalic inclusion disease was found in combination with aspergillosis; in the second with candidiasis.

Aspergillosis is rare in the pediatric age group being most commonly a disease of middle age. Allan and Andersen6 reviewed six cases of primary aspergillosis in childhood to which they

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