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September 1965

Generalized Cytomegalic Inclusion DiseaseReport of Two Cases With Associated Fungal Infection, One Involving Aspergillosis, the Second With Candidiasis

Am J Dis Child. 1965;110(3):319-328. doi:10.1001/archpedi.1965.02090030333019

SINCE RIBBERT,1 in 1904, first reported the presence of inclusion bodies in the cells of the kidney and parotid gland of a stillborn infant and Jesionek and Kiolemenoglou2 similarly cited inclusions in the cells of the kidney, liver, and lungs of another stillborn infant, cytomegalic inclusion disease has been reported frequently as a disease of newborn infants, infants beyond the neonatal period, and less commonly, older children3 and adults.4,6 We wish to report two infants with cytomegalic inclusion disease in combination with a fungal infection, since we could find no definite reports of such cases in infancy. In the first case cytomegalic inclusion disease was found in combination with aspergillosis; in the second with candidiasis.

Aspergillosis is rare in the pediatric age group being most commonly a disease of middle age. Allan and Andersen6 reviewed six cases of primary aspergillosis in childhood to which they