ALTHOUGH RUBELLA is almost invariably a mild, self-limited disease seldom followed by complications or sequelae of any kind, numerous studies have established that at least 15% to 20% of the offspring of women who contract German measles during the first trimester of pregnancy are afflicted with one or more serious and grossly discernible congenital malformations.1-8 Moreover, if audiometric studies are done, an additional 20% to 30% of such children are found to have some impairment of hearing.9 The earlier in pregnancy that maternal rubella occurs, the greater is the hazard to the fetus; thus, 50% or more of the children born of women contracting rubella during the first four weeks of pregnancy may have gross congenital
GREEN RH, BALSAMO MR, GILES JP, KRUGMAN S, MIRICK GS. Studies of the Natural History and Prevention of Rubella. Am J Dis Child. 1965;110(4):348–365. doi:10.1001/archpedi.1965.02090030368003
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