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October 1965

Studies of the Natural History and Prevention of Rubella

Author Affiliations

From the departments of medicine and pediatrics, New York University School of Medicine; the Willowbrook State School, Staten Island, NY; and the Veterans Administration Hospital, New York. Professor of Medicine (Dr. Green); Instructor in Medicine (Dr. Balsamo); Research Associate Professor of Pediatrics and Career Scientist of the Health Research Council of the City of New York (Dr. Giles); Professor of Pediatrics (Dr. Krugman); and Professor of Medicine (Dr. Mirick).

Am J Dis Child. 1965;110(4):348-365. doi:10.1001/archpedi.1965.02090030368003

ALTHOUGH RUBELLA is almost invariably a mild, self-limited disease seldom followed by complications or sequelae of any kind, numerous studies have established that at least 15% to 20% of the offspring of women who contract German measles during the first trimester of pregnancy are afflicted with one or more serious and grossly discernible congenital malformations.1-8 Moreover, if audiometric studies are done, an additional 20% to 30% of such children are found to have some impairment of hearing.9 The earlier in pregnancy that maternal rubella occurs, the greater is the hazard to the fetus; thus, 50% or more of the children born of women contracting rubella during the first four weeks of pregnancy may have gross congenital

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