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October 1965

Rubella Encephalopathy: Later Psychometric, Neurologic, and Encephalographic Evaluation of Seven Survivors

Author Affiliations

From the University of Pittsburgh School of Medicine and the Children's Hospital of Pittsburgh.

Am J Dis Child. 1965;110(4):374-380. doi:10.1001/archpedi.1965.02090030394006

Current textbooks1,2 include rubella with measles and varicella in the group of demyelinating encephalitides, although demyelinization of the brain in rubella encephalopathy has not been documented.3,4 Recently, six cases of rubella encephalopathy were described which occurred during the 1964 rubella epidemic in Pittsburgh.5 Three were fatal, and although survival after the onset of encephalopathy was as long as 8 and 11 days, none had demyelinization. The acute clinical picture and the pathological findings were more like those of acute toxic encephalopathy6,7 than those of postmeasles or postvaricella "encephalitis."

In the initial publication there was little comment on the survivors after discharge from the hospital. If demyelinization had occurred, residua would be expected in the survivors. The purpose of this report is to present the findings of neurologic, psychometric, and encephalographic studies in the three survivors described in the previous communication, as well as in four additional