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October 1965

Experimental Rubella Virus Infection in Pregnant Monkeys

Author Affiliations

From the Laboratory of Viral Immunology, Division of Biologics Standards, National Institutes of Health.

Am J Dis Child. 1965;110(4):390-394. doi:10.1001/archpedi.1965.02090030410008

Introduction  IN A RECENT report from this laboratory, the rhesus monkey was shown to be a useful host for the study of experimental rubella virus infection; these animals develop an infection virologically similar to human rubella.1,2 This experience led to evaluation of the monkey as an animal model for the study of maternal-fetal rubella. Preliminary experiments resolved a number of technical problems, established that the pregnant monkey could be experimentally infected, and demonstrated transplacental transfer of rubella virus neutralizing antibody.2This report describes further investigations in which it was found that rubella virus inoculation of the simian in early gestation frequently led to infection of the products of conception.

Materials and Methods  Virus.—The M33 strain of rubella virus3 in its second to fifth tissue culture passage was employed throughout these studies. These virus preparations had been tested for bacteria, fungi, Mycoplasma, and extraneous viruses.Tissue Cultures

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