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October 1965

Rubella Epidemic, 1964: Effect on 6,000 Pregnancies: I. Preliminary Clinical and Laboratory Findings Through the Neonatal Period: A Report From the Collaborative Study on Cerebral Palsy

Author Affiliations

From the Perinatal Research Branch, National Institute of Neurological Diseases and Blindness; the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases; and the following collaborating institutions: Boston Lying-In Hospital; Brown University; Buffalo Children's Hospital; Charity Hospital, New Orleans; Johns Hopkins Hospital; Medical College of Virginia; Metropolitan Hospital at New York Medical College; Pennsylvania Hospital; the Children's Hospital of Philadelphia; University of Minnesota; University of Oregon; and the University of Tennessee.

Am J Dis Child. 1965;110(4):395-407. doi:10.1001/archpedi.1965.02090030415009

AN EXTENSIVE epidemic of rubella occurred throughout the United States during the first six months of 1964. This epidemic was monitored by 11 institutions participating in the prospective Collaborative Study of Cerebral Palsy. In addition to the detailed clinical data obtained for all pregnant patients and their children in the study, special protocols were instituted to provide detailed information on rubella. Serial serum specimens taken throughout pregnancies were subsequently tested for antibody to rubella.

The present paper presents a preliminary report of the clinical and laboratory findings available through the neonatal period.

Materials and Methods  I. General Study Information.—This report is based on the experience of 6,161 pregnant women who were under study during the period of January through June 1964. These women were registered at collaborating institutions, all of them university hospitals, of which seven are along the eastern seaboard and four at scattered points over the remainder

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