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October 1965

Congenital Rubella Syndrome: Study of 22 Infants: Myocardial Damage and Other New Clinical Aspects

Author Affiliations

From the departments of pediatrics and pathology, University of Tennessee College of Medicine, Memphis, and the Section on Infectious Diseases, Perinatal Research Branch, National Institute of Neurological Diseases and Blindness, Public Health Service, Bethesda, Md.

Am J Dis Child. 1965;110(4):434-440. doi:10.1001/archpedi.1965.02090030454013

THE WIDESPREAD national rubella epidemic in the spring of 1964 resulted in the birth of a large number of abnormal infants. Recently described virologic techniques1-3 have shown that the well known clinical signs of the congenital rubella syndrome are a consequence of active infection.4-6 Isolation of the rubella virus has also documented the etiology of several new clinical signs.

In Memphis, the rubella epidemic of 1964 was at a peak in April. Affected infants first appeared in our nurseries in October of that year. Infants included in this report were born between October 1964 and February 1965. Data are complete on 22 babies. Studies are in progress on a total of 50 infants.

Materials and Methods  The 22 infants herein reported were observed initially during the early neonatal period. All infants but two were studied for no less than four weeks and for a maximum of 15 weeks.

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