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October 1965

Studies on Congenital Rubella: Preliminary Results on the Frequency and Significance of Presence of Rubella Virus in the Newborn and the Effect of γ-Globulin in Preventing Congenital Rubella

Author Affiliations

From the Division of Infectious Diseases and the departments of medicine, microbiology, and pediatrics, University of Cincinnati and Cincinnati General Hospital; and Good Samaritan Hospital, Dayton, Ohio. Associate Director of Medical Education, Good Samaritan Hospital (Dr. Bloom); Associate Professor of Pediatrics and Director of Newborn Service (Dr. Sutherland), Instructor in Pediatrics and Fellow of Newborn Service (Dr. Light), Assistant Professor of Medicine and Microbiology (Dr. Schiff) University of Cincinnati. Dr. Schiff is a Career Development Awardee of the National Institute of Child Health and Development.

Am J Dis Child. 1965;110(4):441-443. doi:10.1001/archpedi.1965.02090030461014

IN 1941, Gregg1 pointed out the existence of congenitally acquired rubella. There have since been many investigations into this problem in an effort to determine its scope, to define the teratogenic mechanisms, and to devise methods to prevent it. Today, 25 years later, we have available the necessary laboratory tools to seek answers in a more definitive manner.2,3 The epidemic which occurred in Cincinnati and Dayton, Ohio, in the spring of 1964 provided an opportunity to study some aspects of congenital rubella. This report will present preliminary findings.

Materials and Methods  The 1,549 infants born at the Cincinnati General Hospital from Oct 15, 1964, to April 1, 1965, were studied. Cord bloods for antibody determination were obtained at delivery. The infants were examined and a pharyngeal swab for viral study was taken within 12 hours of birth. All infants were reexamined at least once before their hospital discharge.

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