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November 1965

Radioactive Iodine Treatment of Graves' Disease: Results in 32 Children Under 16 Years of Age

Author Affiliations

From the departments of general surgery (Dr. Crile) and endocrinology (Dr. Schumacher), The Cleveland Clinic Foundation, Cleveland.

Am J Dis Child. 1965;110(5):501-504. doi:10.1001/archpedi.1965.02090030525002

BETWEEN 1949 and 1961, 32 children with Graves' disease, in the age range of 7 years through 15 years, were treated at the Cleveland Clinic with radioactive iodine (131I).* Their average age was 12 years. Thirty patients, 24 girls and six boys, were treated until their hyperthyroidism was resolved and have been followed to date. (Twelve patients had undergone surgery or received a course of antithyroid drugs before radioactive iodine therapy.) Only one child has not been examined since 131I treatment. Another child (case 5), who lived far away, had a large goiter with severe hyperthyroidism, and was given two doses of 131I. Later she underwent subtotal thyroidectomy for persistent hyperthyroidism. One girl died of a congenital heart lesion three years after 131I therapy but was included in the group.

The dosage of 131I employed in the 30 fully treated patients ranged from a single

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