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November 1965


Author Affiliations

Research Associate University of Michigan Ann Arbor, Mich 48104

Am J Dis Child. 1965;110(5):572-573. doi:10.1001/archpedi.1965.02090030596019

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To the Editor: In reference to the paper "Birth Weight and Gestation as Indices of 'Immaturity' " by Yerushalmy et al (Amer J Dis Child109:43, 1965), I would like to offer a possible explanation of one aspect of the findings which has commanded considerable attention from the authors. That aspect is the inexplicably high proportion of group III children (those weighing over 3 lbs 9 oz, but under 5 lbs, 8 oz and having gestational periods of 37 weeks or longer) who suffered from severe congenital anomalies. Townes et al (J Pediat65:870-879, 1964) have recently formulated an observation commonly made by those familiar with the Trisomy 17-18 syndrome. In their words, "several authors have noted that the Trisomy 17-18 infant is frequently of small size (weight) at birth, despite the fact that the gestation period is generally prolonged (page 877)." More explicitly, from the 40 cases in

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