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December 1965

Studies of Anabolic Steroids: III. The Effect of Oxandrolone on Height and Skeletal Maturation in Mongoloid Children

Author Affiliations

From the Division of Endocrinology and Metabolism, Department of Pediatrics, University of Washington, Seattle, and Rainier State School, Buckley.

Am J Dis Child. 1965;110(6):618-623. doi:10.1001/archpedi.1965.02090030646005

TREATMENT OF growth retardation remains one of the most difficult areas of pediatric care. Various methods of therapy have been attempted but, except in those isolated cases with identifiable specific abnormalities which are amenable to treatment, little success has been achieved.

Among the agents considered to hold some promise for use as growth-promoting agents are the anabolic steroids. Although certain of these drugs have been known for some time and have been employed experimentally in growth-retarded children, their usefulness for promoting growth in such children generally remains in doubt. Reluctance to use them for this purpose is based primarily on the fear of: (1) risking acceleration of skeletal maturation in excess of height attainment, (2) androgenic side effects, and (3) possible other untoward effects.

One of the newer anabolic steroids considered to be of possible use in retarded growth is oxandrolone. It is chemically related to testosterone and described structurally

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