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December 1965

Parotid Saliva in Cystic Fibrosis: II. Electrolytes and Protein-Bound Carbohydrates

Author Affiliations

From the Division of Stomatology, School of Dental and Oral Surgery, Columbia University; Babies Hospital, Columbia-Presbyterian Medical Center; and the Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York.

Am J Dis Child. 1965;110(6):646-651. doi:10.1001/archpedi.1965.02090030674010

EXAMINATION of the parotid saliva affords a convenient means of studying possible aberrations of exocrine gland function in patients with cystic fibrosis of the pancreas. The present study, in two parts, deals with the electrolytes (Part 1) and protein-bound carbohydrates (Part 2) found in the parotid saliva of patients with cystic fibrosis of the pancreas.

Several investigators have reported elevation of sodium and chloride levels in patients with cystic fibrosis where samples were collected without stimulation1,2 and with reflex stimulation.3 However, in another study in which parotid flow was reflexly stimulated, differences in levels of sodium and chloride were reported to be of "borderline significance."4 The calcium and phosphorus content of reflexly stimulated parotid saliva has been reported to be significantly elevated in children with cystic fibrosis.4

Abnormalities in the carbohydrate moieties of glycoproteins have also been reported in duodenal fluid,5 sweat,6 and submaxillary

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