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December 1965

Familial Hypophosphatemic Vitamin D Resistant Rickets: Effect of Increased Oral Calcium and Phosphorus Intake Without High Doses of Vitamin D

Author Affiliations

From the sections of pediatrics (Drs. Stickler and Hayles) and biochemistry (Dr. Rosevear), Mayo Clinic and Mayo Foundation.

Am J Dis Child. 1965;110(6):664-667. doi:10.1001/archpedi.1965.02090030692013

IN 1937, ALBRIGHT and associates1 postulated that a defect in calcium absorption from the gastrointestinal tract exists in vitamin D resistant rickets. A review of the available metabolic balance data supported this observation and indicated that there also may be an increased loss of phosphate in the feces of patients with vitamin D resistant rickets.2

Healing of rickets has been observed after intravenous infusion of phosphate,3 but increased oral intakes of either phosphorus or calcium alone have not produced consistent healing of the rickets; this is particularly true for children.4-6 Thus, it seemed reasonable to attempt control of the bone process by giving increased oral intakes

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