IT HAS BEEN clearly demonstrated that artificial colonization of the nasal mucosa of newborns with one strain of Staphylococcus aureus interferes with subsequent acquisition of a second strain of S aureus.1 This deliberate colonization of infants shortly after birth with a staphylococcal strain of low virulence (strain 502A) has been employed to protect infants from colonization and disease with virulent epidemic strains of S aureus.2-6
Following these observations, studies were extended to two groups of adults. Observations on one group (male, adult volunteers, members of the Federal Penitentiary in Atlanta) emphasized altered resistance of carriers to nasal colonization following administration of sodium oxacillin.7,8
The present observations were made on medical and nursing students at the New York Hospital-Cornell Medical Center primarily to study colonization of oxacillin-and placebo-treated noncarriers by a selected strain of S aureus. Data were also collected on the effect of sodium oxacillin on organisms other than S
SHINEFIELD HR, WILSEY JD, RIBBLE JC, BORIS M, EICHENWALD HF, DITTMAR CI. Interactions of Staphylococcal Colonization: Influence of Normal Nasal Flora and Antimicrobials on Inoculated Staphylococcus aureus Strain 502A. Am J Dis Child. 1966;111(1):11–21. doi:10.1001/archpedi.1966.02090040047002
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