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January 1966

Interactions of Staphylococcal Colonization: Influence of Normal Nasal Flora and Antimicrobials on Inoculated Staphylococcus aureus Strain 502A

Author Affiliations

From the departments of Pediatrics (Drs. Shinefield and Boris and Miss Dittmar) and Medicine (Dr. Ribble), New York Hospital-Cornell Medical Center, and Department of Pediatrics, University of Texas, Southwestern Medical School, Dallas (Dr. Eichenwald). Formerly a medical student at New York Hospital-Cornell Medical Center, New York, Dr. Wilsey is now with the US Army Medical Corps, Trauma Investigation Branch, Biophysics Division, CRDL, Edgewater Arsenal, Maryland. At present Dr. Shinefield is with the Permanente Medical Group, San Francisco.

Am J Dis Child. 1966;111(1):11-21. doi:10.1001/archpedi.1966.02090040047002

IT HAS BEEN clearly demonstrated that artificial colonization of the nasal mucosa of newborns with one strain of Staphylococcus aureus interferes with subsequent acquisition of a second strain of S aureus.1 This deliberate colonization of infants shortly after birth with a staphylococcal strain of low virulence (strain 502A) has been employed to protect infants from colonization and disease with virulent epidemic strains of S aureus.2-6

Following these observations, studies were extended to two groups of adults. Observations on one group (male, adult volunteers, members of the Federal Penitentiary in Atlanta) emphasized altered resistance of carriers to nasal colonization following administration of sodium oxacillin.7,8

The present observations were made on medical and nursing students at the New York Hospital-Cornell Medical Center primarily to study colonization of oxacillin-and placebo-treated noncarriers by a selected strain of S aureus. Data were also collected on the effect of sodium oxacillin on organisms other than S

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