THE IMPORTANT question whether patients receive prescribed oral medication has been raised both in the literature and over the conference table. Because a ten-day therapeutic blood level of penicillin has been found necessary to eradicate group A β-hemolytic streptococci from the pharynx,1,2 the American Heart Association recommends either a single intramuscular injection of 600,000-900,000 units of benzathine penicillin G, intramuscular injections of 300,000-600,000 units of procaine penicillin G with aluminum monostearate given every third day for three doses, or oral penicillin preparations in doses of 200,000-250,000 units administered three times a day for a full ten days.3
Mohler et al in their studies in the home treatment of streptococcal disease, reported that more than one third of their clinic patients were failing to take the prescribed course of orally administered penicillin; they concluded that a single injection of benzathine penicillin G was much more reliable in eradicating streptococcal
LEISTYNA JA, MACAULAY JC. Therapy of Streptococcal Infections: Do Pediatric Patients Receive Prescribed Oral Medication? Am J Dis Child. 1966;111(1):22–26. doi:10.1001/archpedi.1966.02090040058003
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