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January 1966

Coagulation Defects and Giant Cavernous Hemangioma: A Case Study in Infancy

Author Affiliations

From the departments of medicine and pediatrics, University of Cincinnati, College of Medicine, Cincinnati.

Am J Dis Child. 1966;111(1):71-74. doi:10.1001/archpedi.1966.02090040107013

HYPOFIBRINOGENEMIA and associated coagulation defects complicating giant cavernous hemangioma in an infant have been reported rarely.1,2 It is the purpose of this paper to describe such a case. Following radiation therapy the hemangioma regressed and the deficiencies in fibrinogen and other coagulation factors returned to normal.

Materials and Methods  The bleeding time was performed by the method of Ivy3 and the clotting time by the single tube method of Lewis and Glueck.4 Platelet counts were performed by the method of Dameshek.5 The prothrombin time (ProT) was measured by the method of Quick.6 In one instance the ProT was performed after 0.1 ml of a 1% solution of bovine fibrinogen (Armour) was added to both test and normal plasma. Blood-clotting factor V was measured by the method of Stefanini and Dameshek7; factors VII-X complex were measured by methods previously described.8 Factor VIII was assayed