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February 1966

A Method for Approximating the Efficacy of Peritoneal Dialysis for Uremia

Author Affiliations

From the Department of Pediatrics, John Hopkins University School of Medicine, and the Harriet Lane Service of the Johns Hopkins Children's Medical and Surgical Center. At present Dr. Kallen is a postdoctoral trainee (US Public Health Service grant No. T1-AM-5275-04).

Am J Dis Child. 1966;111(2):156-160. doi:10.1001/archpedi.1966.02090050088005

THE RELATIVE ease of performing peritoneal dialysis in small patients has contributed to its widespread use, compared to hemodialysis, in pediatrics. The purpose of this paper is to propose a method for predicting the efficacy of peritoneal dialysis in subjects of different body sizes.

When a uniform, high concentration of a no-threshold solute (such as inulin, mannitol, or urea) is established in the body fluids, the concentration will decrease exponentially until the loading solute is completely removed,1 or, as in the case of urea, until the excretory rate equals the production rate. Estimates of the renal clearance of inulin2 and mannitol3 have been made based on this principle. The renal clearance of such a solute is related to the volume of distribution by,

The symbols are defined as: At, the concentration of the particular solute at any time; Ao, the initial concentration of the solute; e,